Cognition was assessed using validated Hindi version of ACE-III and MMSE among 54 participants with type 2 diabetes and similar number of age, sex, and educational status matched healthy controls. To assess cognitive function in patients with type 2 diabetes using Hindi version of ACE-III and compare its performance with MMSE. Hindi version of Addenbrooke’s Cognitive Examination III is a freely available cognition assessment tool that has been widely used on diverse group of diseases including diabetes. While Mini-Mental State Examination (MMSE) is a widely used tool for the assessment of cognition, it is not available for free for research. CONCLUSIONS The results of this study provide objective validation of the Egyptian-Arabic version of the ACE-III as a screening tool for MCI, with good sensitivity, specificity, and accuracy that are comparable to other translated versions of the ACE-III in MCI.read more read lessĪbstract: There is an increased prevalence of cognitive impairment (CI) in patients with type 2 diabetes thus, there is a need for a sensitive and a convenient screening tool for its detection. Using a receiver operator characteristic curve, the optimal cut-off score for diagnosing MCI on the ACE-III total score was 81, with 75% sensitivity, 82% specificity, and 80% accuracy. There was also a statistically significant difference between MCI patients and controls in the memory, fluency, and visuospatial sub-scores of the ACE-III (p < 0.05) but not in attention and language sub-scores. RESULTS There was a statistically significant difference (p < 0.001) in the total ACE-III score between MCI patients (mean 75.83, standard deviation (SD) 8.1) and controls (mean 86.26, SD 6.74). METHODS A total of 24 patients with MCI and 54 controls were included in the study and were administered the Egyptian-Arabic version of the ACE-III. The aim of this study was to validate Addenbrooke's Cognitive Examination-III (ACE-III) (Egyptian-Arabic version) in a sample of patients with MCI, to provide cut-off scores in Egyptian-Arabic speakers. There is a shortage of validated cognitive screening tools in Arabic to diagnose MCI. An optimized version is suggested which may be an economic alternative in the applied field.read more read lessĪbstract: BACKGROUND AND AIMS Mild cognitive impairment (MCI) represents an important point on the pathway to developing dementia and a target for early detection and intervention. These results can contribute to determining patterns of cognitive deterioration for the adequate detection of different levels of dementia. Furthermore, the information function test shows that the subscales have different sensitivity to different levels of impairment. The results showed that, globally, the Addenbrooke’s Cognitive Examination III possesses adequate psychometrics properties. A cross-sectional study was conducted with 1164 people from the age of 60 upwards, of which 63 had a prior diagnosis of Alzheimer dementia. The aim of this study was to evaluate the psychometric properties of Addenbrooke’s Cognitive Examination III in a large sample of elderly people through Item Response Theory, due to the lack of studies using this approach. Although previous studies have shown adequate levels of diagnostic utility to detect severe impairment, it has not shown sensitivity to detect mild decline. Conclusion Hindi ACE-III has good discriminating power at lower cut-offs than the standard scores in differentiating between MCI and MNCD.read more read lessĪbstract: The Addenbrooke’s Cognitive Examination III is one of the most widely used tests to assess cognitive impairment. Education- and age-stratified cut-offs were also computed. Results The optimal cut-off values to detect MCI and MNCD with ACE-III were 71 and 62 (AUC: 0.849 and 0.884), respectively, which were slightly higher than with HMSE (AUC: 0.822, 0.861). Hindi ACE-III and HMSE were administered and were statistically analyzed. The complete clinical protocol was followed. They were categorized into three groups: healthy controls (n=222), MCI (n=70), and MNCD (n=120). Methods A sample of 412 consenting older adults visiting a memory clinic was recruited into the study. This study aimed to validate the Hindi version of Addenbrooke's Cognitive Examination III (ACE-III) in Indian older adults and compare its validity with the Hindi Mini-Mental State Examination (HMSE). Further, when such tests are culturally and educationally unbiased, it strengthens their diagnostic utility. Abstract: Background Screening and diagnostic tests provide an objective measure of cognitive performance and also aid in distinguishing mild cognitive impairment (MCI) from major neurocognitive disorder (MNCD).
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